Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertension and the heart.

D Susic1, E D Frohlich

  • 1Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA.

Current Hypertension Reports
|November 4, 2000
PubMed
Summary

Hypertension causes left ventricular hypertrophy, increasing cardiovascular risks. This review explores how high blood pressure and aging interact to worsen heart changes and affect circulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-link breakers as a new therapeutic approach to cardiovascular disease.

Biochemical Society transactions·2007
Same author

Isolated systolic hypertension in elderly WKY is reversed with L-arginine and ACE inhibition.

Hypertension (Dallas, Tex. : 1979)·2001
Same author

Heart, aging, and hypertension.

Current opinion in cardiology·2001
Same author

Low-dose ACE with alpha- or beta-adrenergic receptor inhibitors have beneficial SHR cardiovascular effects.

Journal of cardiovascular pharmacology and therapeutics·2001
Same author

Coronary hemodynamic and ventricular responses to angiotensin type 1 receptor inhibition in SHR: interaction with angiotensin type 2 receptors.

Hypertension (Dallas, Tex. : 1979)·2001
Same author

Abnormal renal vascular responses to dipyridamole-induced vasodilation in spontaneously hypertensive rats.

Hypertension (Dallas, Tex. : 1979)·2001

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Cardiac Pathophysiology

Background:

  • Sustained arterial pressure elevation leads to left ventricular hypertrophy (LVH).
  • LVH adversely impacts myocytes, interstitium, and coronary vasculature.
  • Hypertensive heart disease significantly elevates cardiovascular morbidity and mortality risks.

Purpose of the Study:

  • To discuss mechanisms of hypertension-induced myocardial collagen accumulation.
  • To examine impairments in coronary hemodynamics due to hypertension.
  • To analyze the interaction between hypertension and aging on cardiac changes.

Main Methods:

  • Review of existing literature on hypertension-induced cardiac remodeling.
  • Analysis of mechanisms contributing to myocardial fibrosis.
  • Discussion of hemodynamic alterations in the coronary circulation.

Main Results:

  • Hypertension promotes myocardial collagen accumulation and ventricular fibrosis.
  • Coronary circulation is impaired in hypertensive conditions.
  • Aging exacerbates hypertension-induced cardiac changes and fibrosis.

Conclusions:

  • Hypertension-induced myocardial fibrosis and coronary hemodynamic impairments increase cardiovascular risk.
  • The interplay of hypertension and aging worsens cardiac pathology.
  • Therapeutic effects on fibrosis and hemodynamics warrant further investigation.

Related Experiment Videos