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Related Experiment Videos

Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method.

P Giunchedi1, E Gavini, G Bonacucina

  • 1Dipartimento di Scienze del Farmaco, Università di Sassari, Italy. pgiume@ssmain.uniss.it

Journal of Microencapsulation
|November 4, 2000
PubMed
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Emulsification-spray drying effectively created poly(D,L-lactic acid) microparticles for controlled drug delivery. Matrix tablets formulated from these microparticles demonstrated sustained release of sodium naproxen over 8-10 hours.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biomedical Engineering

Background:

  • Poly(D,L-lactic acid) (PDLLA) microparticles are investigated for controlled drug delivery.
  • Water-soluble drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), present formulation challenges.
  • Sustained drug release is crucial for effective therapeutic outcomes.

Purpose of the Study:

  • To develop and characterize poly(D,L-lactic acid) microparticles loaded with sodium naproxen using emulsification-spray drying.
  • To evaluate the drug release profiles of microparticles and compressed matrix tablets.
  • To compare the influence of preparation methods on drug release.

Main Methods:

  • Emulsification-spray drying technique to prepare PDLLA microparticles loaded with sodium naproxen.

Related Experiment Videos

  • Preparation of microparticles via suspension spraying for comparative analysis.
  • Characterization using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD).
  • In vitro drug release testing and direct compression into matrix tablets.

    • Main Results:

    • All spray-dried microparticles released sodium naproxen within 30 minutes.
    • Matrix tablets exhibited controlled drug release over an 8-10 hour period.
    • Matrix tablets containing surfactant (from emulsion method) showed the highest drug release rate.

    Conclusions:

    • Emulsification-spray drying is a viable method for producing PDLLA microparticles loaded with water-soluble drugs.
    • Direct compression of microparticles into matrix tablets enables sustained drug release.
    • Surfactant presence in microparticles influences the drug release kinetics from matrix tablets.