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Updated: Jul 29, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
[Current data on the functional morphology of granulation tissue cells in skin wounds]
Abstract:
The article summarizes the latest literature data on the morphology of the granulation tissue cells: neutrophils, monocytes, macrophages, mast cells and fibroblasts. In the majority of cases these cells were studied with the help of such methods as electron microscopy, histochemical analysis autoradiography. Sources of origin of these cells and dynamics of their development in the period of formation and maturation of the granulation tissue are considered. Findings of the current studies into the structure and functions of fibroblasts and their role in collagen formation, as well as the role of hormonal factors in these processes are analysed in detail.
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