Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An integrated approach to structural genomics.

U Heinemann1, J Frevert, K Hofmann

  • 1Forschungsgruppe Kristallographie, Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, 13122, Berlin, Germany. Heinemann@MDC-Berlin.de

Progress in Biophysics and Molecular Biology
|November 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Emergency room visits for asthma and the reported outcomes: The PASS survey by the CRISALIS network].

Revue des maladies respiratoires·2025
Same author

Treatment of a symptomatic cervical cerebrospinal fluid fistula after full endoscopic cervical foraminotomy with CT-guided epidural fibrin patch.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2023
Same author

The FRESH Study: Treatment of Intracranial Aneurysms with the New FRED X Flow Diverter with Antithrombotic Surface Treatment Technology-First Multicenter Experience in 161 Patients.

AJNR. American journal of neuroradiology·2023
Same author

Third international challenge to model the medium- to long-range transport of radioxenon to four Comprehensive Nuclear-Test-Ban Treaty monitoring stations.

Journal of environmental radioactivity·2022
Same author

[Spontaneous intracranial hypotension with brain sagging and reversible frontotemporal dementia : Case report and review of the literature].

Der Nervenarzt·2022
Same author

[Severe adult asthma and treatment adherence: Results of the FASE-CPHG study].

Revue des maladies respiratoires·2021
Same journal

Nuclear Envelope Rupture Initiation in Confined Migration: A Geometric-Kinetic Framework.

Progress in biophysics and molecular biology·2026
Same journal

Time-Resolved Spectroscopy in Protein Dynamics and Enzyme Mechanisms.

Progress in biophysics and molecular biology·2026
Same journal

Mathematical frameworks for left ventricular assist device therapy: Ventricular mechanics, blood rheology, haemodynamics, control, and nonlinear dynamics.

Progress in biophysics and molecular biology·2026
Same journal

Biological functions of BAF57, its role in disease pathogenesis, and treatment: From molecular mechanisms to clinical translation.

Progress in biophysics and molecular biology·2026
Same journal

Photonics-integrated and AI-enhanced medical sensing: From molecular diagnostics to real-time cell therapy monitoring.

Progress in biophysics and molecular biology·2026
Same journal

Uncovering the Biological Mechanisms of TREM2 with Molecular Simulations: A Comprehensive Review and Perspective.

Progress in biophysics and molecular biology·2026
See all related articles

Structural genomics aims to map all protein structures for homology modeling. The Protein Structure Factory (PSF) will accelerate this by analyzing human proteins using high-throughput methods.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Genomics

Background:

  • Structural genomics seeks to catalog protein structures for comprehensive biological understanding.
  • Homology modeling relies on a representative set of known protein structures.

Purpose of the Study:

  • To establish a low-cost, high-throughput infrastructure for analyzing soluble human proteins.
  • To contribute to the global effort in structural genomics.

Main Methods:

  • Expression of protein-coding genes in E. coli or yeast.
  • Semi-automated purification of affinity-tagged proteins.
  • Structure determination using X-ray diffraction and NMR spectroscopy.

Main Results:

  • Development of a robotic station for protein crystallization.

Related Experiment Videos

  • Establishment of an NMR center.
  • Creation of a synchrotron-based crystallography facility at BESSY II.

    • Conclusions:

    • The Protein Structure Factory (PSF) will enhance structural genomics efforts.
    • Automation, parallelization, and standardization are key to high-throughput structure analysis.
    • The PSF infrastructure supports comprehensive structural description of the protein universe.