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[Prostatic malacoplakia: report of 3 cases]
L Tisseau1, L Zini, L Lemaitre
1Service d'Anatomie et Cytologie Pathologiques, Hôpital Calmette, Lille, France.
Abstract:
Malakoplakia is a granulomatous inflammatory disorder occurring rarely in the prostate. We report our experience with three patients aged from 54 to 75 years old. Clinical presentations were unspecific. All patients presented with a past history of urinary tract infection. Ultrasound study revealed hypoechoic peripheral zone lesions. Histological examination showed a diffuse granulomatous inflammation with numerous histiocytes containing Michaelis-Gutmann bodies. In the prostate, malakoplakia is a histological variant of granulomatous chronic prostatitis following urinary infections. Clinically and radiologically, the differential diagnosis with adenocarcinoma is difficult. The symptoms disappear with a prolongated antibiotic treatment.
Insights
Malakoplakia, a rare prostate condition, presents unspecifically but resolves with antibiotics. This granulomatous inflammation, characterized by Michaelis-Gutmann bodies, mimics cancer on imaging.
Area of Science:
- Urology
- Pathology
- Inflammatory Disorders
Background:
- Malakoplakia is a rare granulomatous inflammatory disorder.
- Prostate involvement is uncommon.
- Often associated with a history of urinary tract infections.
Observation:
- Three male patients (54-75 years) presented with unspecific symptoms.
- Ultrasound revealed hypoechoic peripheral zone lesions.
- Histology showed diffuse granulomatous inflammation with Michaelis-Gutmann bodies.
Findings:
- Prostate malakoplakia is a histological variant of granulomatous chronic prostatitis.
- It often follows urinary tract infections.
- Clinical and radiological presentation can mimic adenocarcinoma.
Implications:
- Early diagnosis is crucial due to potential confusion with prostate cancer.
- Prolonged antibiotic treatment can lead to symptom resolution.
- Highlights the importance of considering inflammatory conditions in prostate diagnostics.