Treatment of pemphigus with cyclophosphamide

Cyclophosphamide was ineffective in controlling acute disease activity in nine of eleven pemphigus patients, but when given during the remission phase even 50 mg cyclophosphamide per day was sufficient to prevent subsequent relapses in all the patients for quite long periods of follow-up. This small dose of cyclophosphamide could be given to outpatients and there were no side effects.