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Related Experiment Videos

Superior bioavailability of digoxin solution in capsules.

G I Mallis, D H Schmidt, J Lindenbaum

    Clinical Pharmacology and Therapeutics
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Digoxin bioavailability from capsules was higher than from tablets, even with faster tablet dissolution. Encapsulated digoxin may offer improved absorption compared to other formulations.

    Area of Science:

    • Pharmacokinetics
    • Drug Formulation

    Background:

    • Digoxin bioavailability varies significantly across different oral formulations.
    • Dissolution rate is a key factor influencing digoxin absorption from tablets.

    Purpose of the Study:

    • To compare the bioavailability of various digoxin formulations.
    • To investigate the impact of dissolution rate on digoxin absorption.

    Main Methods:

    • Single and multiple dose crossover studies in human volunteers.
    • Assessment of serum and urinary digoxin levels.
    • In vitro dissolution testing of digoxin tablets.

    Main Results:

    • Digoxin capsules demonstrated greater bioavailability than tablets, irrespective of tablet dissolution rate.

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  • Encapsulated digoxin (0.4 mg) achieved similar serum levels to higher doses of tablet formulations (0.5 mg).
  • No increase in toxicity was observed with the encapsulated formulation.

    • Conclusions:

    • Dissolution rate is not the sole determinant of digoxin absorption; other factors enhance bioavailability of encapsulated digoxin.
    • Concentrated liquid digoxin in capsule form shows potential as a superior alternative to digoxin tablets.