Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reduced leptin levels in human narcolepsy.

A Schuld1, W F Blum, M Uhr

  • 1Max Planck Institute of Psychiatry Munich, Germany. schuld@mpipsykl.mpg.de

Neuroendocrinology
|November 9, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetics of rapid eye movement sleep in humans.

Translational psychiatry·2015
Same author

FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.

Molecular psychiatry·2015
Same author

RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response.

Translational psychiatry·2015
Same author

RSUME inhibits VHL and regulates its tumor suppressor function.

Oncogene·2014
Same author

Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala.

Translational psychiatry·2014
Same author

Plasma fibrinogen: now also an antidepressant response marker?

Translational psychiatry·2014
Same journal

Passive Smoking and Thyroid Diseases: Association by Mendelian Randomization Study.

Neuroendocrinology·2026
Same journal

Erratum.

Neuroendocrinology·2026
Same journal

Stress as a Neuroendocrine Modulator of the Reproductive Axis: Roles of Glucocorticoids, Kisspeptin and Serotonergic Signalling in Animal Models.

Neuroendocrinology·2026
Same journal

Pathological Classification and Clinical Characteristics of Growth Hormone-Secreting PitNETs.

Neuroendocrinology·2026
Same journal

Proximal-to-distal gradient and its implications in differentiation and prognosis in colorectal neuroendocrine neoplasms: the RGETNE-HERACLES study.

Neuroendocrinology·2026
Same journal

Inflammatory Signaling and Emotional Symptoms in Hashimoto's Thyroiditis Beyond Thyroid Function Status.

Neuroendocrinology·2026
See all related articles

Narcolepsy patients show significantly lower serum leptin levels, indicating metabolic and appetite regulation disturbances. This suggests a link between narcolepsy, body mass index, and hormonal imbalances affecting food intake.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Sleep Medicine

Background:

  • Narcolepsy is a sleep disorder linked to hypocretin deficiency.
  • Narcolepsy patients often have increased body mass index (BMI), suggesting metabolic dysregulation.
  • Leptin, a hormone from fat cells, signals satiety and energy balance to the brain.

Purpose of the Study:

  • To investigate alterations in leptin production in narcolepsy patients.
  • To explore the relationship between narcolepsy, BMI, and food intake regulation.

Main Methods:

  • Measured serum and cerebrospinal fluid (CSF) leptin levels in 15 narcolepsy patients.
  • Compared narcolepsy patients to age-, sex-, and BMI-matched control groups (depressive and non-inflammatory neurological disorders).

Related Experiment Videos

Main Results:

  • Narcolepsy patients exhibited over 50% lower serum leptin levels compared to both control groups.
  • No significant difference in CSF leptin levels was observed between narcolepsy patients and controls.

Conclusions:

  • Narcolepsy is associated with significant reductions in serum leptin.
  • These findings support the hypothesis of complex alterations in food intake and metabolism regulation in narcolepsy.
  • Further research is needed to understand the clinical significance of these metabolic changes in narcolepsy symptoms.