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Myasthenia gravis associated with reduced masticatory function.

Y Sasakura1, S Kumasaka, T Takahashi

  • 1First Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Japan. sasakura@kdcnet.ac.jp

International Journal of Oral and Maxillofacial Surgery
|November 9, 2000
PubMed
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This case study highlights a rare initial symptom of myasthenia gravis: chewing difficulty. Treatment improved bite force, correlating with reduced anti-acetylcholine receptor antibody levels.

Area of Science:

  • Neurology
  • Immunology
  • Oral Medicine

Background:

  • Myasthenia gravis (MG) is a rare autoimmune disorder affecting neuromuscular junctions.
  • Common initial symptoms include diplopia and ptosis, but other presentations exist.

Observation:

  • A 38-year-old woman presented with chewing difficulty, initially seeking dental and oral surgery consultation.
  • This symptom is an uncommon initial manifestation of myasthenia gravis.

Findings:

  • The patient received steroid therapy and underwent thymectomy for myasthenia gravis.
  • Bite force monitoring revealed low levels correlating with high anti-acetylcholine receptor antibody titers (11.0 nmol/l).
  • Therapy led to decreased antibody titers (1.5 nmol/l) and increased bite force.

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Implications:

  • Chewing difficulty can be a rare presenting symptom of myasthenia gravis.
  • Monitoring bite force may offer insights into MG treatment efficacy.
  • This case underscores the importance of considering systemic conditions for orofacial symptoms.