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Virus mutators and antimutators: roles in evolution, pathogenesis and emergence.

L M Mansky1, K S Cunningham

  • 1Department of Molecular Virology, Immunology and Medical Genetics, Center for Retrovirus Research, Comprehensive Cancer Center, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210-1239, USA.

Trends in Genetics : TIG
|November 14, 2000
PubMed
Summary

Virus mutator and antimutator alleles, known in bacteriophage T4, are poorly understood in human viruses. These genetic variants significantly impact virus evolution, disease emergence, and antiviral treatment effectiveness.

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Area of Science:

  • Virology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Mutator and antimutator alleles were identified in bacteriophage T4 over 30 years ago.
  • Limited knowledge exists regarding these genetic variants in human viruses.
  • These variants influence mutation rates within viral populations.

Purpose of the Study:

  • To highlight the limited understanding of mutator and antimutator alleles in human viruses.
  • To emphasize the potential significance of these variants in viral evolution and pathogenesis.
  • To underscore their implications for antiviral therapy.

Main Methods:

  • This study is a review and synthesis of existing knowledge.
  • It focuses on the implications of mutator/antimutator alleles in viral systems.

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  • Comparative analysis between bacteriophage T4 and human viruses is implied.

    • Main Results:

    • Mutator and antimutator alleles significantly alter viral mutation frequencies.
    • Their presence in human viruses could accelerate evolution and adaptation.
    • These genetic variants may pose challenges for developing effective antiviral treatments.

    Conclusions:

    • Understanding mutator and antimutator alleles in human viruses is crucial.
    • These variants play a key role in viral evolution, pathogenesis, and emergence.
    • Further research is needed to explore their impact on antiviral drug resistance.