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Updated: Aug 15, 2026

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
Published on: March 16, 2011
Virus mutators and antimutators: roles in evolution, pathogenesis and emergence
1Department of Molecular Virology, Immunology and Medical Genetics, Center for Retrovirus Research, Comprehensive Cancer Center, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210-1239, USA.
Abstract:
Virus mutators (mutant alleles that confer a higher mutant-frequency phenotype than that of the wild type) and antimutators (mutant alleles that confer a lower mutant-frequency phenotype) were discovered in bacteriophage T4 over three decades ago, but there is only limited detailed knowledge about such genetic variants in viruses that infect humans and threaten public health. The creation of mutators and antimutators during the course of viral infection (particularly in the case of RNA viruses) could play a pivotal role in virus evolution, pathogenesis and emergence, and could also frustrate antiviral therapy.
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