Related Experiment Video
Updated: Aug 5, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
NF-kappaB as a therapeutic target in chronic inflammation: recent advances
1Thurston Arthritis Research Center, Center for Inflammatory Disorders, and Department of Endodontics, University of North Carolina at Chapel Hill, 27599-7280, USA. smak@med.unc.edu
Abstract:
The family of nuclear factor kappaB (NF-kappaB) transcription factors is a topic of intense interest in the biomedical community stemming from the role NF-kappaB plays in almost every aspect of cell regulation: stress responses, immune cell activation, apoptosis, proliferation, differentiation and oncogenic transformation. The objective of this article is to provide an overview of recent developments in the field with an emphasis on the role of NF-kappaB in chronic inflammation, and to discuss the feasibility of therapeutic approaches based on the specific suppression of the NF-kappaB pathway.
More Related Videos
Related Concept Videos
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Chronic Inflammation: Introduction

