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Related Experiment Videos

Serological pattern "anti-HBc alone": report on a workshop.

P Grob1, W Jilg, H Bornhak

  • 1Clinical Immunology, University Hospital Zürich, Switzerland.

Journal of Medical Virology
|November 14, 2000
PubMed
Summary
This summary is machine-generated.

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Individuals with isolated hepatitis B core antibody (anti-HBc) may have chronic hepatitis B virus (HBV) infection and can be infectious. Further research is needed on clinical aspects and transmission risks.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Isolated "anti-HBc alone" antibody is detected in 1-4% of the general population in low endemicity areas.
  • Hepatitis B virus (HBV) DNA is found in about 10% of these individuals, with higher rates in those coinfected with hepatitis C virus (HCV) or human immunodeficiency virus (HIV).
  • A small proportion represent the window phase or late immunity, but many likely have unresolved or low-grade chronic HBV infection.

Framework:

  • This study reviews current knowledge on the clinical significance of isolated "anti-HBc alone" positivity.
  • It highlights the limited existing research on the clinical aspects of individuals with suspected chronic HBV infection and isolated anti-HBc.
  • The focus is on understanding the implications of this serological marker.

Implementation:

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  • Analysis of existing data on HBV DNA detection rates in isolated anti-HBc positive individuals.
  • Review of clinical presentations, including asymptomatic carriers and those with chronic hepatitis.
  • Assessment of potential HBV transmission through sexual contact, perinatal routes, and blood recipients.

Implications:

  • Individuals with isolated anti-HBc can be infectious, posing risks for transmission.
  • Recommendations are provided for diagnostic and therapeutic strategies in managing these individuals.
  • Guidelines are suggested for blood banking and transplantation services to mitigate transmission risks.