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Updated: Aug 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Expression and function of androgen receptor in carcinoma of the prostate

Z Culig1, A Hobisch, G Bartsch

  • 1Department of Urology, University of Innsbruck, A-6020 Innsbruck, Austria. Zoran.Culig@uibk.ac.at

Microscopy Research and Technique
|November 14, 2000
PubMed

Insights

Androgen receptors remain in prostate cancer even when resistant to androgens. This review covers how androgen receptor expression and function are regulated, offering insights into treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Androgen receptor (AR) plays a critical role in prostate cancer development and progression.
  • Understanding AR regulation is crucial, as androgen-resistant prostate cancers still express AR.

Purpose of the Study:

  • To review recent findings on androgen receptor expression, structure, and function in prostate cancer.
  • To summarize the regulation of AR expression and function by various factors.
  • To discuss the role of AR-associated proteins in pathological conditions.

Main Methods:

  • Literature review of recent findings on androgen receptor.
  • Synthesis of information on AR regulation, function, and associated proteins.

Main Results:

  • Androgen receptor expression and function are regulated by androgens, growth factors, and protein kinase A activators.
  • Both wild-type and mutant AR functions are modulated by androgens and nonsteroidal activators.
  • AR activity influences the transcription of AR-regulated genes in a cell type-dependent manner.
  • AR-associated proteins, coactivators, and corepressors may play roles in prostate cancer pathology.

Conclusions:

  • Despite the development of androgen resistance, androgen receptors are present and actively involved in prostate cancer.
  • Further research into AR regulation and associated proteins may lead to novel therapeutic strategies for advanced prostate cancer.

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