Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene transfer in wound healing.

E Eriksson1

  • 1Division of Plastic Surgery, Brigham and Women's/Children's Hospital, Boston, MA, USA.

Advances in Skin & Wound Care
|November 15, 2000
PubMed
Summary

Gene transfer introduces nucleic acids into cells to modify cellular functions. This powerful technique enables targeted delivery of proteins to enhance wound healing and treat genetic defects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of intratumoral immunostimulatory LOAd703 gene therapy combined with chemotherapy in patients with advanced cancer.

Immuno-oncology technology·2026
Same author

LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial.

Nature communications·2026
Same author

Correction for Göransson et al., "Performance of a System for Rapid Phenotypic Antimicrobial Susceptibility Testing of Gram-Negative Bacteria Directly From Positive Blood Culture Bottles".

Journal of clinical microbiology·2023
Same author

Preceptors' experiences of supervising internationally educated nurses attending a bridging program: An interview study.

Nurse education today·2023
Same author

Performance of a System for Rapid Phenotypic Antimicrobial Susceptibility Testing of Gram-Negative Bacteria Directly from Positive Blood Culture Bottles.

Journal of clinical microbiology·2023
Same author

Three paths to a Swedish nursing license: Two for internationally educated nurses and one for regular nursing students - A cross-sectional study of self-rated professional competence, self-efficacy, and thriving.

Nurse education today·2022

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Gene transfer involves introducing DNA or RNA into cells to express proteins, potentially altering cellular functions.
  • Effective delivery of therapeutic proteins to target sites, like healing wounds, remains a challenge.

Purpose of the Study:

  • To review and summarize current gene transfer techniques for cellular expression.
  • To highlight the potential of gene transfer for therapeutic applications, particularly in wound healing.

Main Methods:

  • Overview of viral vectors (e.g., adenoviral vectors for in vivo wound transfection).
  • Description of chemical vectors (liposomes, calcium phosphate, diethylaminoethyl-dextran).
  • Explanation of mechanical methods (direct injection, gene gun, microseeding).

Main Results:

  • Current gene transfer methods achieve protein expression for 1-2 weeks.
  • Gene transfer allows for targeted, local delivery of high concentrations of peptides to wounds.
  • Controllable gene expression using systems like the tetracycline switch is feasible.

Conclusions:

  • Gene transfer is a versatile tool for delivering therapeutic proteins, including stimulatory and inhibitory peptides, to wound environments.
  • This technology holds significant promise for treating wounds with specific biochemical or genetic defects.
  • Further research into gene transfer techniques can advance localized protein delivery for regenerative medicine.

Related Experiment Videos