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[Multifocal osteosarcoma. A case report].

S Zafad¹, A Madani, M Harif

¹Service d'hématologie et d'oncologie pédiatriques, hôpital 20 Août 1953, Casablanca, Maroc.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|November 15, 2000

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Multifocal osteosarcoma, a rare and aggressive bone cancer, presents with multiple tumors. This aggressive form of osteosarcoma has a poor prognosis despite intensive chemotherapy treatments.

Area of Science:

Oncology
Orthopedic Oncology
Pediatric Oncology

Background:

Multifocal osteosarcoma is a rare and aggressive variant of osteosarcoma.
It accounts for 1-10% of all osteosarcoma cases.
Histologically, it often presents as osteoblastic osteosarcoma.

Observation:

A case study involved a 12-year-old boy with multifocal osteosarcoma.
Initial presentation included a skull tumor with pleural and pulmonary nodules.
The patient subsequently developed additional skull tumors, a shoulder tumor, and pelvic lesions.

Findings:

Computed tomography revealed a calcified lesion with intra- and extracranial extension.
Biopsy confirmed an osteoblastic osteosarcoma.
Radiographic studies showed further lytic lesions at new sites.

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Implications:

The patient showed no response to high-dose methotrexate and doxorubicin chemotherapy.
Multifocal osteosarcoma carries a poor prognosis despite aggressive treatment.
Ongoing debate exists regarding whether this represents true multifocality or an unusual metastatic pattern.