Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spine changes associated with long-term potentiation.

D Muller1, N Toni, P A Buchs

  • 1Neuropharmacology, Centre Médical Universitaire, Geneva, Switzerland. Dominique.Muller@medecine.unige.ch

Hippocampus
|November 15, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stimulation of testosterone production by atrial natriuretic peptide in isolated mouse Leydig cells results from a promiscuous activation of cyclic AMP-dependent protein kinase by cyclic GMP.

Molecular and cellular endocrinology·1992
Same author

Lethal micromelic facial bones sclerosis dysplasia.

The British journal of radiology·1992
Same author

Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry.

Biochemistry·1992
Same author

[Determination of exocrine pancreatic function in childhood with the pancreozymin-secretin test].

Kinderarztliche Praxis·1992
Same author

[Failure to thrive in young children--disorders of carbohydrate absorption?].

Kinderarztliche Praxis·1992
Same author

[Hazards in the surgical field].

Deutsche Krankenpflegezeitschrift·1992
Same journal

Opioid-Associated Hippocampal Injury: Past, Present, and Future Directions.

Hippocampus·2026
Same journal

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory.

Hippocampus·2026
Same journal

Intrinsic Persistent Firing in CA1 Encodes Elapsed Time Across Behaviorally Relevant Scales.

Hippocampus·2026
Same journal

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.

Hippocampus·2026
Same journal

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.

Hippocampus·2026
Same journal

Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on In Vivo Dentate Gyrus Long-Term Potentiation in the TgF344-AD Rat Model of Alzheimer's Disease.

Hippocampus·2026
See all related articles

Structural changes in brain synapses, known as long-term potentiation (LTP), are crucial for learning and memory. Research suggests that the physical remodeling of dendritic spines underlies this important synaptic plasticity.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Synaptic Plasticity

Background:

  • Long-term potentiation (LTP) enhances synaptic transmission, contributing to learning and memory.
  • The stability of LTP is hypothesized to involve structural remodeling of dendritic spine synapses.
  • Dendritic spines are dynamic structures influenced by synaptic activity and calcium levels.

Purpose of the Study:

  • To review and interpret recent findings on the structural basis of LTP.
  • To explore the role of postsynaptic density (PSD) remodeling and spine duplication in LTP.
  • To integrate these structural insights with current understanding of LTP mechanisms, including glutamate receptor dynamics.

Main Methods:

  • Review of ultrastructural analyses and recent experimental studies on synaptic plasticity.

Related Experiment Videos

  • Interpretation of data concerning spine dynamics, shape changes, and formation.
  • Integration of findings with knowledge of postsynaptic glutamate receptor turnover.

    • Main Results:

    • Spines are highly dynamic and can form rapidly, with activity and calcium modulating their structure.
    • Ultrastructural evidence indicates LTP is associated with PSD remodeling and spine duplication.
    • Morphological changes in spine synapses correlate with and likely contribute to increased synaptic transmission.

    Conclusions:

    • Structural remodeling of dendritic spine synapses is a key feature associated with long-term potentiation (LTP).
    • These morphological changes, including PSD remodeling and spine duplication, are not merely correlated with LTP but actively contribute to the enhancement of synaptic transmission.
    • Understanding these structural dynamics provides critical insights into the mechanisms of learning and memory at the synaptic level.