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Related Experiment Videos

Carcinoembryonic antigen and bladder carcinoma.

G Ionescu, N A Romas, L Ionascu

    The Journal of Urology
    |January 1, 1976
    PubMed
    Summary

    24-hour urinary carcinoembryonic antigen (CEA) tests show high elevation in 81% of bladder cancer patients with active tumors. This urinary CEA test is a promising biomarker for bladder carcinoma detection and staging.

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    Area of Science:

    • Uro-oncology
    • Biomarker Discovery
    • Clinical Chemistry

    Background:

    • Bladder carcinoma is a significant global health concern.
    • Accurate and early detection of bladder cancer is crucial for effective treatment.
    • Carcinogenic embryonic antigen (CEA) is a known tumor marker, but its role in bladder cancer requires further elucidation.

    Purpose of the Study:

    • To evaluate the diagnostic utility of 24-hour urinary carcinoembryonic antigen (CEA) levels in patients with bladder carcinoma.
    • To compare the efficacy of urinary CEA with plasma CEA in detecting active bladder tumors.
    • To investigate the correlation between urinary CEA levels and the stage of bladder cancer.

    Main Methods:

    • Prospective study involving 61 patients diagnosed with bladder carcinoma.

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  • Collection and analysis of 24-hour urine samples for CEA concentration.
  • Measurement of plasma CEA levels in the same patient cohort.
  • Correlation of CEA levels with tumor activity and clinical staging.

    • Main Results:

    • Elevated 24-hour urinary CEA titers were observed in 81% of patients with active bladder tumors.
    • False positive results for urinary CEA were noted in 7% of cases.
    • Higher stages of bladder carcinoma were associated with significantly higher urinary CEA levels.
    • Plasma CEA levels were elevated in only 45% of patients with active tumors, suggesting lower sensitivity.

    Conclusions:

    • 24-hour urinary CEA determination demonstrates a high sensitivity for detecting active bladder carcinoma.
    • Urinary CEA appears to be a more sensitive biomarker than plasma CEA for bladder cancer.
    • Further research is warranted to define the precise clinical application of urinary CEA in managing bladder cancer, particularly in advanced stages.