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Updated: Aug 15, 2026

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry
Published on: March 13, 2014
Clathculins A and B, two novel nitrogen-containing metabolites from the sponge Clathrina aff. reticulum
A Rudi1, M Schleyer, Y Kashman
1School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel.
Abstract:
Two novel acyclic diaza alkenynes, clathculins A and B (1 and 2), were isolated from the Indo-Pacific sponge Clathrina aff. reticulum collected in Sodwana Bay, South Africa. The structure of the mixture of the two unstable inseparable compounds was established by spectroscopic analysis, mainly 1D and 2D NMR measurements and two chemical transformations. Clathculins A and B are the first reported linear marine metabolites containing a 1,2-diaminoethane moiety.
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