Hantavirus pulmonary syndrome associated with Monongahela virus, Pennsylvania
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Updated: Oct 10, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
L V Rhodes1, C Huang, A J Sanchez
1Lehigh Valley Hospital, Allentown, Pennsylvania, USA. luther.rhodes@lvh.com
Abstract:
The first two recognized cases of rapidly fatal hantavirus pulmonary syndrome in Pennsylvania occurred within an 8-month period in 1997. Illness in the two patients was confirmed by immunohistochemical techniques on autopsy material. Reverse transcription-polymerase chain reaction analysis of tissue from one patient and environmentally associated Peromyscus leucopus (white-footed mouse) identified the Monongahela virus variant. Physicians should be vigilant for such Monongahela virus-associated cases in the eastern United States and Canada, particularly in the Appalachian region.
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