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Carcinoid tumourlets associated with diffuse bronchiectasis and intralobar sequestration
M Dewan1, T S Malatani, O Osinowo
1Department of Pathology, Assir Central Hospital, Abha, Saudi Arabia.
The Journal of the Royal Society for the Promotion of Health
|November 15, 2000
Summary
Carcinoid tumourlets in the lung can cause chronic lung disease, especially when associated with intralobar sequestration. Early resection of intralobar sequestration may prevent these complications.
Area of Science:
- Pulmonary Medicine
- Thoracic Surgery
- Pathology
Background:
- Intralobar sequestration can lead to scarring and subsequent development of carcinoid tumourlets.
- Carcinoid tumourlets are small neuroendocrine cell proliferations that can cause chronic lung disease.
Observation:
- A 65-year-old man with a history of recurrent lung infections, dyspnea, and hemoptysis presented with incidentally detected multifocal carcinoid tumourlets.
- Surgical resection of the left lower lobe revealed diffuse bronchiectasis, intralobar sequestration with aberrant systemic arterial supply, and loss of demarcation between sequestered and normal lung parenchyma.
Findings:
- The multifocal carcinoid tumourlets were likely an adaptive response to chronic hypoxia.
- The combination of intralobar sequestration, bronchiectasis, and carcinoid tumourlets is uncommon but associated with un-resected sequestration.
Implications:
- This case highlights the potential link between intralobar sequestration, chronic hypoxia, and the development of carcinoid tumourlets.
- Prompt surgical intervention for intralobar sequestration may prevent the development of these associated pulmonary complications.
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