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Low-grade Central Osteosarcoma with High-grade Transformation in the Distal Tibia: A Rare Case Report
Tarang Patel1, Gyanendra Singh1, Vaishali Bhankhodia1
1Department of Pathology, All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Journal of Orthopaedic Case Reports
|August 14, 2026
Summary
Low-grade central osteosarcoma (LGCO) is a rare bone cancer that can mimic benign conditions, posing diagnostic challenges. This case highlights LGCO
Area of Science:
- Orthopedic Oncology
- Skeletal Pathology
- Surgical Reconstruction
Background:
- Low-grade central osteosarcoma (LGCO) is a rare bone malignancy (1-2% of osteosarcomas) often mistaken for benign fibro-osseous lesions.
- LGCO typically shows indolent behavior but can undergo malignant transformation to a high-grade form.
- Accurate diagnosis is challenging due to overlapping radiologic and histologic features with benign conditions.
