Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK

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P Richmond1, R Borrow, D Goldblatt

  • 1Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, London, United Kingdom.

The Journal of Infectious Diseases
|November 15, 2000
PubMed

Insights

A single dose of meningococcal C conjugate (MCC) vaccine in toddlers effectively builds immunologic memory, demonstrated by robust antibody responses and avidity increases after a booster dose, supporting its use in catch-up immunization programs.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Assessing immunologic memory after meningococcal C conjugate (MCC) vaccination in toddlers is crucial for public health strategies.
  • Understanding vaccine-induced immune responses informs optimal immunization schedules.

Purpose of the Study:

  • To evaluate the immunologic memory and antibody responses following a single dose of different MCC vaccines in toddlers.
  • To determine the efficacy of a booster dose in enhancing immune memory.

Main Methods:

  • A randomized trial involving 226 toddlers (12-18 months) receiving one of three MCC vaccines (MCC-CRM(197) or MCC-TT).
  • Serum bactericidal antibody (SBA) titers and IgG antibody avidity were measured at baseline, 1 month, and 6 months post-vaccination.
  • A polysaccharide booster was administered at 6 months, with subsequent immune response assessment.

Main Results:

  • One month post-vaccination, 91%-100% of children achieved protective SBA titers (> or =8).
  • MCC-TT demonstrated superior SBA geometric mean titers (GMT) and higher proportions of protective titers compared to MCC-CRM(197).
  • By 6 months, antibody levels decreased but IgG avidity increased, indicating developing immunologic memory. A booster dose significantly boosted GMT and avidity.

Conclusions:

  • A single dose of MCC vaccine induces significant immunologic memory in toddlers.
  • The MCC-TT vaccine elicited a stronger initial immune response than MCC-CRM(197).
  • The findings support the use of a single MCC vaccine dose in catch-up immunization programs for children aged 1-18 years.

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