Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostate tissue and serum markers.

R Mazzucchelli1, P Colanzi, R Pomante

  • 1Institutes of Pathological Anatomy, University of Ancona School of Medicine, Torrette, Ancona Italy.

Advances in Clinical Pathology : the Official Journal of Adriatic Society of Pathology
|November 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantification of bone marrow edema by MRI of the sacroiliac joints in patients diagnosed with axial spondyloarthritis: results from the ESPeranza cohort.

Scandinavian journal of rheumatology·2021
Same author

Pathology without microscope: From a projection screen to a virtual slide.

Pathology, research and practice·2020
Same author

Risk of acute myocardial infarction among new users of bisphosphonates: a nested case-control study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Epigenetic modulations and lineage plasticity in advanced prostate cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Focal laser ablation as clinical treatment of prostate cancer: report from a Delphi consensus project.

World journal of urology·2019
Same author

Short-term association between outdoor air pollution and osteoporotic hip fracture.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018

Serum prostate specific antigen (PSA) levels can indicate prostate cancer (PCa) but also benign conditions like BPH. Further PSA indices and markers improve PCa detection, though early detection of PIN remains debated.

Area of Science:

  • Urology
  • Oncology
  • Biochemistry

Background:

  • Elevated serum prostate specific antigen (PSA) above 4.0 ng/ml is common in prostate cancer (PCa).
  • Benign prostatic hyperplasia (BPH) can also elevate serum PSA, reducing specificity for PCa detection.
  • Atypical small acinar proliferation (ASAP) on biopsy may indicate underdiagnosed PCa, often with elevated serum PSA.

Purpose of the Study:

  • To evaluate the diagnostic utility of serum PSA and related markers for prostate cancer.
  • To explore the role of PSA indices and alternative markers in improving PCa detection accuracy.
  • To investigate the potential of serum PSA in identifying early-stage prostatic intraepithelial neoplasia (PIN).

Main Methods:

  • Analysis of serum PSA levels and calculation of PSA-related indices (PSA density, velocity, percent free PSA).

Related Experiment Videos

  • Evaluation of additional serum markers, including human glandular kallikreins and prostate specific membrane antigen.
  • Correlation of serum marker levels with biopsy findings, including PCa, BPH, ASAP, and PIN.

    • Main Results:

    • Serum PSA alone demonstrates limited sensitivity and specificity for distinguishing PCa from BPH.
    • PSA-related indices and other serum markers partially enhance diagnostic accuracy for PCa.
    • The utility of serum PSA for detecting isolated PIN prior to PCa development requires further investigation.

    Conclusions:

    • Serum PSA is an imperfect marker for prostate cancer due to overlap with benign conditions.
    • Advanced PSA-based calculations and novel biomarkers offer improved, though not definitive, PCa detection.
    • The role of serum PSA in the early identification of PIN remains an open question.