Related Experiment Video
Updated: Aug 12, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
Spectroscopic monitoring of batch reactions for on-line fault detection and diagnosis
1Department of Chemical Engineering, University of Amsterdam, The Netherlands.
Abstract:
This paper presents the general methodology to use spectroscopic measurements directly for on-line process monitoring and detection and diagnosis of disturbances. An application of the on-line monitoring of a chemical batch reaction using UV-visible spectroscopy is discussed in detail. Successful historical batches are used to build a statistical model of the batch reaction. The model uses external information such as the pure spectra of the compounds and their concentration profiles to improve the interpretability. Control charts are developed for on-line monitoring of new batches. It is shown that this model is capable of detecting erroneous batches. In combination with contribution plots, the actual cause of the disturbances can be diagnosed.
More Related Videos
Related Concept Videos
Measuring Reaction Rates
Gas Chromatography: Types of Detectors-II
High-Performance Liquid Chromatography: Types of Detectors
Controlled-Current Coulometry: Overview
Fast Reactions
Bioreactor Controls-I

