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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Final Amended Safety Assessment of Octyldodecyl Stearoyl Stearate as Used in Cosmetics

Regina Tucker1, Wilma F Bergfeld2, Donald V Belsito2

  • 1Cosmetic Ingredient Review Former Scientific Analyst/Writer.

International Journal of Toxicology
|October 12, 2026
PubMed

Keywords:
Cosmetic Ingredient ReviewCosmeticsExpert Panel for Cosmetic Ingredient SafetyOctyldodecyl Stearoyl StearateSafety

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Esters to Carboxylic Acids: Saponification01:25

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Esters can be hydrolyzed to carboxylic acids under acidic or basic conditions. Base-promoted hydrolysis of esters is a nucleophilic acyl substitution reaction in which esters react with an aqueous base, followed by an acid to give carboxylic acids. This reaction is also known as saponification because it forms the basis for making soaps from fats.
The reaction requires a base in stoichiometric amounts, which participates in the reaction and is not regenerated later. So, the base acts as a...