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Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis

N Coyle, I Jones, E Robertson

    Lancet (London, England)
    |November 18, 2000
    PubMed

    Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.

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