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Synthesis of C(3) benzofuran-derived bisaryl quaternary centers: approaches to diazonamide A
D E Fuerst1, B M Stoltz, J L Wood
1Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
Organic Letters
|November 18, 2000
Abstract:
[reaction: see text] Two complementary strategies for the synthesis of the diazonamide A bisaryl quaternary center are described. The first strategy relies upon an extremely facile tandem cyclopropanation/ring-opening sequence, which has proven amenable to chiral catalysis to provide enantioenriched material. The second strategy relies upon a more concise alkylation route ideal for material advancement.