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Nitric oxide donors.

T Yamamoto1, R J Bing

  • 1Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, California 91101, USA.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|November 18, 2000
PubMed
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Nitric oxide (NO) donors release NO, impacting platelet aggregation, angiogenesis, and cardiac function. This review covers their characteristics, effects, and challenges like NO tolerance, particularly in myocardial infarction and tumors.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Cardiovascular Science

Background:

  • Nitric oxide (NO) is a molecule with diverse physiological roles, including regulating blood vessel tone, platelet aggregation, and inflammation.
  • Nitric oxide donors are compounds designed to release NO in the body, offering therapeutic potential.
  • Understanding the multifaceted actions of NO is crucial for developing effective treatments.

Purpose of the Study:

  • To review the chemical and pharmacological properties of nitric oxide donors.
  • To examine the effects of NO donors on platelet function, cyclooxygenase activity, and cardiac actions.
  • To discuss the implications of NO donors in myocardial infarction, angiogenesis, and solid tumors, including the phenomenon of NO tolerance.

Main Methods:

  • Literature review of existing studies on nitric oxide donors.

Related Experiment Videos

  • Analysis of chemical and pharmacological data related to NO release and action.
  • Synthesis of findings concerning NO donor effects on various physiological and pathological processes.

    • Main Results:

    • Nitric oxide donors exhibit varied pharmacological profiles and release NO through different mechanisms.
    • NO donors influence platelet aggregation, prostanoid release, and superoxide anion production.
    • Evidence suggests a role for NO donors in modulating angiogenesis in conditions like myocardial infarction and solid tumors, alongside challenges posed by NO tolerance.

    Conclusions:

    • Nitric oxide donors represent a significant class of pharmacologically active compounds with broad physiological effects.
    • Their application in cardiovascular diseases and oncology warrants further investigation, particularly concerning the development of NO tolerance.
    • Comprehensive understanding of NO donor characteristics is essential for optimizing their therapeutic use and mitigating adverse effects.