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Updated: Aug 11, 2026
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Simultaneous Recordings of Cortical Local Field Potentials, Electrocardiogram, Electromyogram, and Breathing Rhythm from a Freely Moving Rat
Published on: April 2, 2018
Reversible transitions between synchronization states of the cardiorespiratory system
A Stefanovska1, H Haken, P V McClintock
1Group of Nonlinear Dynamics and Synergetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia.
Physical Review Letters
|November 18, 2000
Summary
Cardiac and respiratory phase synchronization in rats reveals distinct states during anesthesia. Changes in synchronization patterns may indicate the depth of anesthesia.
Area of Science:
- Physiology
- Biophysics
- Anesthesiology
Background:
- Cardiac and respiratory rhythms are fundamental physiological processes.
- Anesthesia profoundly impacts autonomic nervous system regulation.
- Understanding physiological dynamics under anesthesia is crucial for patient safety.
Purpose of the Study:
- To investigate the relationship between cardiac and respiratory phase synchronization.
- To determine if anesthesia depth influences these synchronization patterns.
- To explore the potential of synchronization as a biomarker for anesthesia depth.
Main Methods:
- Utilized synchrograms to analyze phase synchronization.
- Employed time evolution of synchronization indices.
- Conducted experiments on rats under varying anesthesia levels.
Main Results:
- Observed reversible transitions between different phase-synchronized states.
- Demonstrated that anesthesia level directly affects synchronization patterns.
- Indicated the occurrence of phase transition-like phenomena.
Conclusions:
- Phase synchronization between cardiac and respiratory oscillations is a dynamic process under anesthesia.
- Synchronization states can be reversibly altered by anesthesia depth.
- Cardiac-respiratory synchronization shows potential for monitoring anesthesia depth.
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