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[Umbilical cord blood cytokines: a new diagnostic parameter? A preliminary report]
P Szołomicka-Kurzawa1, R Kurzawa, R Czajka
1Kliniki Połoznictwa i Perinatologii Pomorskiej Akademii Medycznej w Szczecinie.
Abstract:
The aim of neonatologist is to anticipate clinical status of newborn immediately after delivery. Important are all parameters helpful in determining perinatal outcome. Particular attention is paid to proinflammatory cytokines: IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF alpha. The aim was to verify a relationships between umbilical cord blood cytokines and way of delivery, umbilical factor and clinical status of newborn in perinatal period. Newborns with lower 10 min Apgar score had higher levels of umbilical blood cytokines. Elevated IL-6 and IL-8 levels were found in newborns with subsequently diagnosed bacterial infection. Higher levels of cytokines were found in umbilical blood of newborns who passed meconium into the amniotic sac and who required an incubator. Proinflammatory cytokines, especially IL-6 and IL-8 may indicate the newborn clinical status in perinatal period.