Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene expression microarray data analysis for toxicology profiling.

M J Cunningham1, S Liang, S Fuhrman

  • 1Incyte Pharmaceuticals, Incorporated, Palo Alto, California 94304, USA. maryjane@incyte.com

Annals of the New York Academy of Sciences
|November 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Sleep problems and the association with the levels of 6-sulfatoxymelatonin in children with autism spectrum disorder].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2017
Same author

CD44V6 regulates gastric carcinoma occurrence and development through up-regulating VEGF expression.

European review for medical and pharmacological sciences·2017
Same author

The association between oral health status and respiratory pathogen colonization with pneumonia risk in institutionalized adults.

International journal of dental hygiene·2017
Same author

Thulium-fiber-laser-pumped, high-peak-power, picosecond, mid-infrared orientation-patterned GaAs optical parametric generator and amplifier.

Optics letters·2017
Same author

Low-loss Kagome hollow-core fibers operating from the near- to the mid-IR.

Optics letters·2017
Same author

Effects of C/N ratio on the performance of a hybrid sponge-assisted aerobic moving bed-anaerobic granular membrane bioreactor for municipal wastewater treatment.

Bioresource technology·2017
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
Same journal

Synchrony and Reciprocity in Rhythmic Interaction.

Annals of the New York Academy of Sciences·2026
See all related articles

Scientists can rank genes for physiological processes using Shannon entropy and ERL. Genes with high values are promising toxicity targets, guiding preclinical research and resource allocation.

Area of Science:

  • Genomics
  • Toxicology
  • Bioinformatics

Background:

  • Identifying key genes in complex physiological processes is challenging.
  • Thousands of genes require evaluation for potential roles in toxicity.
  • Efficient methods are needed to prioritize genes for further study.

Purpose of the Study:

  • To develop a method for ranking genes based on their involvement in physiological processes.
  • To identify reliable toxicity target candidates for preclinical research.

Main Methods:

  • Utilizing Shannon entropy to quantify gene expression variability.
  • Employing Enhanced Regression Learning (ERL) to analyze gene participation.
  • Ranking genes based on combined Shannon entropy and ERL scores.

Related Experiment Videos

Main Results:

  • Genes with the highest Shannon entropy and ERL scores were identified.
  • These high-scoring genes represent potential key players in physiological processes and toxicity.

Conclusions:

  • Shannon entropy and ERL provide a robust framework for ranking genes.
  • Prioritizing genes using this method allows preclinical scientists to focus on high-potential toxicity targets.