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[lymphocytic colitis associated with lansoprazole treatment]
J M Ghilain1, M Schapira, J M Maisin
1Unité de Gastroentérologie, Hôpital de Jolimont, Haine-St-Paul, Belgique.
Gastroenterologie Clinique Et Biologique
|November 21, 2000
Summary
Two patients experienced severe diarrhea due to lymphocytic colitis while taking lansoprazole. Symptoms resolved quickly after discontinuing the medication, suggesting a link between lansoprazole and this gastrointestinal condition.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Proton pump inhibitors (PPIs) like lansoprazole are widely used for acid-related gastrointestinal disorders.
- Drug-induced colitis is an uncommon but significant adverse effect of various medications.
Observation:
- Two patients presented with severe, persistent diarrhea.
- Histopathological examination revealed lymphocytic colitis in both cases.
- Both patients had been treated with lansoprazole for approximately six weeks prior to symptom onset.
Findings:
- Lansoprazole treatment was identified as the likely causative agent for lymphocytic colitis in these patients.
- Discontinuation of lansoprazole led to rapid and complete resolution of severe diarrhea.
- This suggests a potential causal relationship between lansoprazole and drug-induced lymphocytic colitis.
Implications:
- Clinicians should consider lansoprazole as a potential cause of lymphocytic colitis in patients presenting with unexplained severe diarrhea.
- Awareness of this adverse effect may improve diagnosis and management of drug-induced gastrointestinal symptoms.
- Further research is warranted to elucidate the mechanisms underlying lansoprazole-induced lymphocytic colitis.