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Updated: Aug 14, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Pros and cons of inhibiting cholesteryl ester transfer protein
K Hirano1, S Yamashita, Y Matsuzawa
1Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan. khirano@kb3.so-net.ne.jp
Abstract:
Whether or not it is desirable to inhibit cholesteryl ester transfer protein (CETP) has been an important question for over fifteen years since genetic CETP deficiency was found. Recently, some epidemiological studies which have been reported in Japan as well as Western countries help to clarify the atherogenicity of human subjects with mutations or polymorphisms in the CETP gene. In addition, some experimental atherosclerosis studies, in which CETP was inhibited in rabbits with different approaches, have been reported. There was a considerable difference in the atherogenicity of human CETP deficiency and CETP-inhibited rabbits. In this review, we summarize the recent advances in this field as well as discussing the significance of CETP in reverse cholesterol transport, a major protective system against atherosclerosis.
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