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Zebrafish Hsp40 and Hsc70 genes are both induced during caudal fin regeneration
1Université Pierre et Marie Curie, Biochimie des Signaux Régulateurs Cellulaires et Moléculaires, UMR 7631 du CNRS, 96, Boulevard Raspail, 75006, Paris, France.
Mechanisms of Development
|November 25, 2000
Abstract:
We report the characterization of a zebrafish DnaJ-like protein, homologue to the human Hsp40 protein hdj1, that we named zf-Hsp40. We have studied its expression during fin regeneration and we show that zf-Hsp40 mRNA level is drastically increased in all ray segments beneath the regenerated part, or blastema, in response to caudal fin amputation. In order to investigate whether zf-Hsp40 is part of a stress response system after injury, we studied the expression of the zebrafish Hsc70 transcript. Our results show a correlation between the expression of the two transcripts.