Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chicken synucleins: cloning and expression in the developing embryo.

A A Tiunova1, K V Anokhin, A R Saha

  • 1P.K. Anokhin Institute of Normal Physiology, Baltyiskaya Street, Moscow, Russia.

Mechanisms of Development
|November 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Behavioral characteristics of rapid visual categorization learning in domestic chicks.

Learning & behavior·2026
Same author

Changing practices in gadolinium-enhanced direct magnetic resonance arthrography: a UK based survey.

The British journal of radiology·2025
Same author

Memory reconsolidation impairment by amyloid beta (1-42) and its prevention by non-competitive antagonists of NMDA receptors.

Frontiers in cellular neuroscience·2025
Same author

Birmingham atypical cartilaginous tumour imaging protocol (BACTIP) revisited.

Clinical radiology·2025
Same author

Non-competitive NMDA antagonist MK-801 prevents memory reconsolidation impairment caused by protein synthesis inhibitors in young chicks.

Frontiers in pharmacology·2024
Same author

Periostitis Ossificans: Largest Case Series with Review of Literature.

The Indian journal of radiology & imaging·2023
Same journal

Corrigendum to "Mechanisms of stress-related muscle atrophy in fish: An ex vivo approach"[Mech. Dev. (2018) 162-169].

Mechanisms of development·2020
Same journal

Conservation analysis of core cell cycle regulators and their transcriptional behavior during limb regeneration in Ambystoma mexicanum.

Mechanisms of development·2020
Same journal

Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.

Mechanisms of development·2020
Same journal

Fetal programming by high-fat diet promoted the decreased of the prostate in adult Wistar albino rats.

Mechanisms of development·2020
Same journal

Pancreas development and the Polycomb group protein complexes.

Mechanisms of development·2020
Same journal

The Cdx transcription factors and retinoic acid play parallel roles in antero-posterior position of the pectoral fin field during gastrulation.

Mechanisms of development·2020
See all related articles

Synucleins are proteins linked to Parkinson's disease and other neurodegenerative conditions. This study reveals conserved functions of synucleins in embryonic development across vertebrates, using chicken embryos to study their expression patterns.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Synucleins are intracellular proteins implicated in neurodegenerative diseases like Parkinson's.
  • Alpha-synuclein mutations and aggregates are hallmarks of alpha-synucleinopathies.
  • Beta-synuclein and gamma-synuclein (persyn) are also found in neurodegenerative disease-associated neurites and persyn is linked to breast cancer.

Purpose of the Study:

  • To investigate the role of synucleins in embryonic nervous system development.
  • To explore synuclein expression patterns in a chicken embryo model.
  • To determine if synuclein functions are conserved between birds and mammals.

Main Methods:

  • Cloning of three chicken synuclein genes from embryonic neural cDNA libraries.

Related Experiment Videos

  • Northern and in situ hybridization techniques to study gene expression.
  • Analysis of synuclein expression in normal chicken embryonic tissues.

    • Main Results:

    • Chicken synucleins were cloned and their expression patterns analyzed.
    • Expression patterns of chicken synucleins were found to be similar to those in mammals.
    • Primary structures of synucleins are conserved between avian and mammalian species.

    Conclusions:

    • Synucleins play a significant role in the development of the vertebrate nervous system.
    • The conserved structure and expression patterns suggest a conserved biological function for synucleins.
    • Chicken embryos provide a valuable model for studying synuclein functions in vivo during development.