Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kubo1, Fukumitsu, Nagata

  • 1Departments of Surgery, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105, Japan.

Breast Cancer (Tokyo, Japan)
|November 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose-Response Effect of Dietary Docosahexaenoic Acid on Fatty Acid Profiles of Serum and Tissue Lipids in Rats.

Journal of agricultural and food chemistry·2001
Same author

Anomalous substituent effects in the bischler-napieralski reaction of 2-aryl aromatic formamides

The Journal of organic chemistry·2001
Same author

Peroxynitrite formation by diesel exhaust particles in alveolar cells: Links to pulmonary inflammation.

Environmental toxicology and pharmacology·2001
Same author

Toxicity of methylmercury conjugated with L-cysteine on rat thymocytes and human leukemia K562 cells in comparison with that of methylmercury chloride.

Environmental toxicology and pharmacology·2001
Same author

Histopathologic comparison of anti-mitochondrial antibody-positive primary biliary cirrhosis and autoimmune cholangiopathy.

Hepatology research : the official journal of the Japan Society of Hepatology·2001
Same author

Catalytic Activity of Hexokinase in Reversed Micelles.

Journal of colloid and interface science·2000
Same journal

Abemaciclib plus endocrine therapy in chemotherapy-treated patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.

Breast cancer (Tokyo, Japan)·2026
Same journal

Functional characterization of BRCA2 variants of uncertain significance identified in Korean breast cancer patients.

Breast cancer (Tokyo, Japan)·2026
Same journal

Quality of life with palbociclib plus tamoxifen in hormone receptor-positive, HER2-negative advanced breast cancer: results from PATHWAY, an Asian international, double-blind, randomized phase 3 trial.

Breast cancer (Tokyo, Japan)·2026
Same journal

Prognostic impact of radiotherapy dose to the axilla in cN + /ypN0 breast cancer after primary systemic therapy and sentinel lymph node biopsy: toward true de-escalation of axillary management.

Breast cancer (Tokyo, Japan)·2026
Same journal

Breast ultrasound screening in young adult women undergoing infertility treatment at an infertility clinic: a retrospective observational study.

Breast cancer (Tokyo, Japan)·2026
Same journal

Prognostic impact of progesterone receptor status in patients with breast cancer and isolated locoregional recurrence.

Breast cancer (Tokyo, Japan)·2026
See all related articles

This study compared thallium-201 (Tl) and technetium-99m-methoxy-2 isobutyl isonitrile (Tc-MIBI) scintigraphy for breast tumor diagnosis. Tc-MIBI showed higher specificity and tumor-to-background ratio, suggesting its greater utility.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Diagnostic Imaging

Background:

  • Breast cancer diagnosis relies on accurate imaging techniques.
  • Thallium-201 (Tl) and Technetium-99m-methoxy-2 isobutyl isonitrile (Tc-MIBI) are radiotracers used in scintigraphy.

Purpose of the Study:

  • To compare the diagnostic performance of Tl and Tc-MIBI scintigraphy in breast tumors.
  • To evaluate the accuracy of these methods in detecting lymph node metastasis.

Main Methods:

  • A comparative study involving 39 breast tumors.
  • Tl scintigraphy performed on 24 tumors; Tc-MIBI scintigraphy on 15 tumors.
  • Assessment of sensitivity, specificity, and tumor/background ratios.

Main Results:

Related Experiment Videos

  • Tl sensitivity was 100% (22/22) but specificity was 0% (0/2).
  • Tc-MIBI sensitivity was 83.3% (10/12) with 100% specificity (3/3).
  • Both agents showed 93.3% accuracy for lymph node metastasis; combined ultrasonography and scintigraphy improved accuracy to 94.4%.

Conclusions:

  • Tc-MIBI may be more useful for breast tumor diagnosis due to higher specificity and tumor/background ratio.
  • Combined ultrasonography and scintigraphy enhance lymph node metastasis detection accuracy.