Related Experiment Video

Updated: Aug 6, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

Hormone Refractory Prostate Cancer and Fibroblast Growth Factor Receptor

Matsubara1, Yasumoto, Usui

  • 1Department of Urology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Breast Cancer (Tokyo, Japan)
|November 25, 2000
PubMed

Insights

Alterations in fibroblast growth factor (FGF) signaling disrupt prostate cancer cell communication, leading to hormone independence. Restoring FGFR2IIIb expression inhibits growth and promotes differentiation, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Prostate cancer progression involves changes in fibroblast growth factor (FGF) signaling pathways.
  • Disrupted communication between stroma and epithelium contributes to cancer cell autonomy.

Purpose of the Study:

  • To investigate the role of FGF receptor alterations in prostate cancer progression.
  • To explore the therapeutic potential of targeting FGF signaling pathways.

Main Methods:

  • Analyzing alterations in FGF and FGF receptor (FGFR) expression during prostate cancer progression.
  • Utilizing transfection techniques to introduce FGFR2IIIb and FGFR1 into prostate cancer cells.

Main Results:

  • Loss of FGFR2IIIb and activation of FGFR1 are observed in hormone-independent prostate cancer.
  • Transfection of FGFR2IIIb inhibits growth and induces differentiation in hormone-independent cells.
  • Introduction of FGFR1 accelerates malignancy in hormone-dependent prostate cancer cells.

Conclusions:

  • Specific FGF pathway alterations drive prostate cancer progression and malignancy.
  • Targeting FGFR2IIIb and FGFR1 presents a potential therapeutic strategy for prostate cancer.
  • Restoring FGFR2IIIb may re-establish homeostasis and inhibit the malignant phenotype.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include: