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Fluorescent labelling of oligodeoxyribonucleotides by the oxyamino-aldehyde coupling reaction
E Trévisiol1, A Renard, E Defrancq
1Chimie BioOrganique, LEDSS, UMR 5616, Université Joseph Fourier, Grenoble, France.
Nucleosides, Nucleotides & Nucleic Acids
|November 25, 2000
Abstract:
We describe the reaction of oligonucleotides containing an aldehydic group at the 5'-end or inside the sequence with an oxyamino label. The reaction was found to be highly selective and represents an efficient method for derivatization of oligonucleotides.