Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Moderate hypoxia exposure and fetal development.

P Astrup, D Trolle, H M Olsen

    Archives of Environmental Health
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gender differences in the effects of cardiovascular drugs.

    European heart journal. Cardiovascular pharmacotherapy·2017
    Same author

    Expert position paper on the use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy.

    European heart journal·2013
    Same author

    Oblique laser-sheet visualization.

    Applied optics·2010
    Same author

    Investigations of postoperative shock; haemoconcentration, plasma protein and blood electrolytes after gastrectomy.

    Acta chirurgica Scandinavica·2010
    Same author

    Induction of labour by means of partergin (Sandoz)an ergot alkaloid.

    Acta obstetricia et gynecologica Scandinavica·2010
    Same author

    On the determination of heparin in blood plasma and urine.

    Acta pharmacologica et toxicologica·2010

    Pregnant rabbits exposed to low oxygen (hypoxia) had smaller babies and higher neonatal mortality. This suggests pregnant smokers at high altitudes face increased risks of low birth weight and infant death.

    Area of Science:

    • Reproductive physiology
    • Environmental health
    • Neonatal health

    Background:

    • Hypoxia during pregnancy is a known risk factor for adverse birth outcomes.
    • Carbon monoxide exposure also negatively impacts fetal development.

    Purpose of the Study:

    • To investigate the effects of moderate hypoxia on pregnancy outcomes in rabbits.
    • To compare hypoxia effects with carbon monoxide exposure.
    • To assess potential additive effects of hypoxia and carbon monoxide.

    Main Methods:

    • Pregnant rabbits were exposed to 15.5% oxygen.
    • Birth weight and neonatal mortality were recorded.
    • Outcomes were compared to control groups and previous carbon monoxide studies.

    Related Experiment Videos

    Main Results:

    • A 17% decrease in birth weight was observed in the hypoxia-exposed group.
    • Neonatal mortality increased to 19% compared to 1% in controls.
    • Effects were comparable to moderate carbon monoxide exposure.

    Conclusions:

    • Moderate hypoxia during pregnancy significantly reduces birth weight and increases neonatal mortality in rabbits.
    • Findings suggest additive risks for pregnant women exposed to both hypoxia (e.g., high altitude) and carbon monoxide (e.g., smoking).
    • High-risk pregnancies require targeted warnings regarding environmental exposures.