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Ozone and human blood.

R D Buckley, J D Hackney, K Clark

    Archives of Environmental Health
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Short-term ozone exposure in adult males altered red blood cells (RBCs) and serum, increasing fragility and lipid peroxidation. These biochemical changes in erythrocytes and sera persisted for two weeks post-exposure.

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    Area of Science:

    • Environmental Health
    • Biochemistry
    • Toxicology

    Background:

    • Ozone (O3) is a significant air pollutant with known respiratory effects.
    • Understanding the systemic impact of ozone exposure on human physiology is crucial.

    Purpose of the Study:

    • To investigate the biochemical and cellular effects of acute ozone exposure on human erythrocytes and serum.
    • To determine the duration of these ozone-induced alterations.

    Main Methods:

    • Young adult males were exposed to 0.50 ppm ozone for 2.75 hours.
    • Erythrocyte and serum parameters including enzyme activities, glutathione levels, vitamin E, and lipid peroxidation were analyzed.

    Main Results:

    • Ozone exposure increased RBC membrane fragility, G-6-PDH, and LDH activities.

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  • Decreased RBC acetylcholinesterase activity and reduced glutathione levels were observed.
  • Serum showed decreased GSSRase activity, increased vitamin E, and elevated lipid peroxidation.
  • Alterations persisted for at least two weeks post-exposure.

    • Conclusions:

    • Acute ozone exposure induces significant oxidative stress and membrane damage in human erythrocytes and serum.
    • Biochemical markers of ozone toxicity remain detectable for up to two weeks, indicating a prolonged systemic effect.