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Published on: May 29, 2017
Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma
P A Brennan1, M Palacios-Callender, T Umar
1BUPA Research Fellow, Maxillofacial Department, University of Portsmouth, Portsmouth, UK.
The British Journal of Oral & Maxillofacial Surgery
|November 28, 2000
Summary
Wild-type p53 protein down-regulates nitric oxide synthase type II (NOS2) expression, inhibiting cancer growth. This study found a significant correlation between p53 and NOS2 in oral squamous cell carcinoma.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Nitric oxide (NO) production by nitric oxide synthase type II (NOS2) is linked to cancer angiogenesis and metastasis.
- Wild-type p53 protein down-regulates NOS2 expression in animal models, reducing tumor growth and spread.
Purpose of the Study:
- To investigate the correlation between p53 and NOS2 expression in oral squamous cell carcinoma (OSCC).
Main Methods:
- Immunohistochemical assessment of NOS2 and p53 (clone DO-7) in 56 OSCC cases.
- Confirmation of NOS2 protein expression via immunoblotting.
- Correlation of findings with clinicopathological data.
Main Results:
- A significant relationship was observed between p53 and NOS2 expression (P=0.001).
- No correlation was found between NOS2 expression and tumor size or histological differentiation grade in primary tumors.
Conclusions:
- p53 status is significantly associated with NOS2 expression in oral squamous cell carcinoma.
- These findings suggest a potential therapeutic target for managing OSCC progression.
