Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomeres and their control.

M J McEachern1, A Krauskopf, E H Blackburn

  • 1University of Georgia, Department of Genetics, Athens, Georgia, 30602, USA. mjm@arches.uga.edu

Annual Review of Genetics
|November 28, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virtual monoenergetic images from spectral detector computed tomography facilitate washout assessment in arterially hyper-enhancing liver lesions.

European radiology·2020
Same author

Fatal attack on a pedestrian by an escaped circus elephant.

Forensic science international·2019
Same author

Meditation and vacation effects have an impact on disease-associated molecular phenotypes.

Translational psychiatry·2016
Same author

Sugary beverage and food consumption, and leukocyte telomere length maintenance in pregnant women.

European journal of clinical nutrition·2016
Same author

Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.

Translational psychiatry·2015
Same author

[Clinical forensic imaging. Detection and documentation of internal injuries in living victims of violence].

Der Radiologe·2015

Telomeres, protective DNA protein complexes at chromosome ends, are maintained by mechanisms like telomerase. This review details how these processes control telomere length and function, preventing genomic instability.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Telomeres are crucial DNA-protein structures protecting chromosome ends.
  • Recent advances have significantly improved understanding of telomere maintenance mechanisms and functions.
  • Telomere dysfunction is linked to genomic instability.

Purpose of the Study:

  • To review the components of the telomere/telomerase complex.
  • To elucidate the control mechanisms governing processes at telomeres.
  • To highlight the interplay between telomere maintenance and genomic stability.

Main Methods:

  • Literature review of current research on telomere biology.
  • Analysis of molecular mechanisms involved in telomere maintenance.
  • Synthesis of information on telomeric DNA and protein interactions.

Related Experiment Videos

Main Results:

  • Identified key components of the telomere/telomerase functional complex.
  • Detailed processes controlling telomeric DNA and proteins, including replication and telomerase-mediated elongation.
  • Described homologous recombination's role in telomere restoration.
  • Highlighted degradative processes and non-homologous end-joining as threats to telomere function.

Conclusions:

  • Telomere maintenance involves a complex interplay of restorative and degradative processes.
  • Tight control over these mechanisms is essential for preventing telomere loss and maintaining genomic stability.
  • Understanding telomere dynamics is critical for comprehending cellular health and disease.