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Updated: Oct 10, 2026

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
Published on: April 23, 2015
Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come
1Hypnion Inc, Five Biotech, 381 Plantation Street, Worcester, Massachusetts 01605, USA. kjm@hypnion.aol.com
Abstract:
In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse (). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.
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