Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequence complexity of disordered protein.

P Romero1, Z Obradovic, X Li

  • 1School of Electrical Engineering and Computer Science, Washington State University, Pullman, Washington 99164-4660, USA. promero@ai.sri.com

Proteins
|November 28, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

Journal of chemical information and modeling·2026
Same author

Factors affecting the efficacy of human leukocyte antigen-selected platelet provision: A large retrospective study in the United Kingdom.

Transfusion medicine (Oxford, England)·2025
Same author

Effect of Kono-S anastomosis on reducing postoperative recurrence rates in Crohn's disease: a systematic review and meta-analysis.

Techniques in coloproctology·2024
Same author

A cost-utility study of elective haemorrhoidectomies in Canada.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2024
Same author

Novel Ameloblastin Variants, Contrasting Amelogenesis Imperfecta Phenotypes.

Journal of dental research·2023
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same journal

Engineered HSP90-MP65 Bivalent Fusion Antigen: A Novel Vaccine Candidate Against Invasive Candidiasis.

Proteins·2026
Same journal

Physics-Based Energy Functions for Computational Protein Design.

Proteins·2026
Same journal

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides.

Proteins·2026
Same journal

Stabilization of Bone Morphogenetic Protein-2 at Physiological pH: Contrasting Roles of CHAPS and Arginine in Aggregation Inhibition.

Proteins·2026
Same journal

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase.

Proteins·2026
Same journal

Generalizing the Gaussian Network Model: Spanning-Tree Thermodynamics Shows Entropy-Driven KRAS Activation.

Proteins·2026
See all related articles

Intrinsically disordered proteins lack fixed 3D structures and are rich in specific amino acids. These disordered protein segments are more common in nature than previously thought.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Proteins may lack fixed 3D structures, a property known as intrinsic disorder.
  • This disorder can exist in proteins within their native state.
  • Understanding disorder is key to understanding protein function.

Purpose of the Study:

  • To investigate the relationship between intrinsic disorder, sequence complexity, and amino acid composition.
  • To compare disorder characteristics in structurally characterized proteins versus larger sequence databases.
  • To identify amino acid biases associated with intrinsically disordered protein regions.

Main Methods:

  • Analysis of protein crystal structures and NMR data.
  • Circular dichroism spectroscopy.

Related Experiment Videos

  • Sequence complexity analysis using Shannon's entropy.
  • Bioinformatic prediction of intrinsically disordered regions.
  • Comparison of Swiss Protein database with Protein Data Bank sequences.

    • Main Results:

    • Disordered proteins and segments show lower sequence complexity distributions than ordered proteins.
    • Intrinsically disordered regions are enriched in amino acids R, K, E, P, S and depleted in C, W, Y, I, V.
    • The Swiss Protein database contains significantly more low-complexity and disordered segments than the Protein Data Bank.

    Conclusions:

    • Intrinsic disorder is linked to specific amino acid compositions and reduced sequence complexity.
    • Nature appears to possess a higher abundance of intrinsically disordered and low-complexity protein segments than is represented in structurally characterized protein sets.
    • These findings highlight the prevalence and characteristics of disordered proteins in biological systems.