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Effect of topical steroid on non-retractile prepubertal foreskin by a prospective, randomized, double-blind study
1Division of Paediatric Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T.
Objective:
The present study, conducted in Hong Kong, aimed to evaluate the effect of topical steroid in non-retractile prepubertal foreskin by a prospective, randomized, double-blind design.
Material And Methods:
137 boys with non-retractile foreskin were randomized to betamethasone (n = 66) or placebo (n = 71 ) for 4 weeks with application of the cream twice daily. Non-responders to treatment were offered steroid treatment for a further 4 weeks.
Results:
The mean pretreatment grade of the foreskin in the steroid and control groups was 5.08 +/- 0.66 and 4.97 +/- 0.70, respectively. At the 4-week follow-up, 49 of the former (74%) had a retractile foreskin (grade less than or equal to 3, mean 2.38 +/- 1.41). In contrast, only 31 of the control group (44%) had a retractile foreskin (less than or equal to 3, mean 3.55 +/- 1.55) (p < 0.001). Only 14 boys were circumcised because 43 of the remaining 57 boys had a retractile foreskin after 4 weeks of treatment.
Conclusion:
when treatment is necessary, application of topical steroid as a first line of treatment may avoid surgery in almost 90% of cases.
