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Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
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Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
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Related Experiment Video

Updated: Jul 13, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
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Published on: December 8, 2011

Candiduria: When and How to Treat It.

Fisher1

  • 1Department of Medicine, Medical College of Georgia, 1120 Fifteenth Street, CB 1831, Augusta, GA 30912, USA. jfisher@mail.mcg.edu

Current Infectious Disease Reports
|November 30, 2000
PubMed
Summary

Candiduria, or yeast in urine, requires careful evaluation. Asymptomatic cases often don't need antifungal treatment; focus on predisposing factors. Treatment options exist for severe infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Urology

Background:

  • Candiduria presents a diagnostic challenge, ranging from contamination to severe fungal infections.
  • Distinguishing true infection from contamination is crucial for appropriate patient management.
  • Understanding patient status and clinical context is key to evaluating candiduria.

Purpose of the Study:

  • To review the significance and evaluation of candiduria.
  • To outline management strategies for asymptomatic and symptomatic candiduria.
  • To discuss the role of various antifungal agents in treating urinary tract fungal infections.

Main Methods:

  • Literature review of clinical findings and management of candiduria.
  • Analysis of diagnostic validation and patient assessment protocols.

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  • Evaluation of antifungal treatment options, including amphotericin B, azoles, and flucytosine.

    • Main Results:

    • Asymptomatic candiduria in stable patients typically does not require antifungal therapy.
    • Management should prioritize addressing predisposing factors when feasible.
    • Parenteral amphotericin B is indicated for severe, widespread infections or resistant Candida.
    • Fluconazole is a primary choice for susceptible strains, though optimal dosing is not established.
    • Intravesical amphotericin B is more valuable diagnostically than therapeutically.

    Conclusions:

    • Proper evaluation of candiduria involves validating funguria, considering the clinical setting, and assessing patient status.
    • Treatment decisions for candiduria should be individualized based on clinical presentation and pathogen susceptibility.
    • Antifungal agents like amphotericin B, fluconazole, and flucytosine have specific roles in managing urinary tract candidiasis.