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Chemotherapy of Colorectal Cancer
1The University of Texas M. D. Anderson Cancer Center, Division of Medicine, 1515 Holcombe Blvd., Box 78, Houston, Texas 77030.
Adjuvant chemotherapy improves survival for stage III colon cancer patients. New agents like CPT-11 show promise for advanced colorectal cancer, offering new treatment options.
Area of Science:
- Oncology
- Gastrointestinal Oncology
- Cancer Therapeutics
Background:
- Adjuvant 5-fluorouracil (5-FU) and leucovorin improve survival in stage III colon cancer.
- Adjuvant therapy benefits for stage II colon cancer remain unproven.
- Adjuvant chemoradiation is standard for stage II and III rectal cancer.
Purpose of the Study:
- To review recent advancements in adjuvant and metastatic colorectal carcinoma treatment.
- To identify potential high-risk stage II colon cancer patients who may benefit from adjuvant therapy.
- To explore novel chemotherapeutic agents and treatment modalities.
Main Methods:
- Review of current literature on colorectal carcinoma treatment strategies.
- Analysis of survival data for adjuvant and metastatic settings.
- Evaluation of new agents like CPT-11, UFT, and oxaliplatin.
Main Results:
- Established survival benefit of 5-FU/leucovorin in stage III colon cancer.
- CPT-11 demonstrates efficacy in 5-FU refractory patients and offers survival advantage over supportive care.
- UFT and oxaliplatin show activity in colorectal carcinomas.
Conclusions:
- Further research is needed to identify stage II colon cancer patients who benefit from adjuvant treatment.
- CPT-11 is a new standard for refractory metastatic colorectal cancer.
- Emerging agents like UFT and oxaliplatin hold future therapeutic potential for colorectal cancer.
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