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Huntington's Disease.

Haskins1, Harrison

  • 1Huntington's Disease Program, University of Virginia Health System 394, Charlottesville, VA 22908, USA.

Current Treatment Options in Neurology
|November 30, 2000
PubMed
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Huntington's disease is an inherited neurodegenerative disorder causing movement, psychiatric, and cognitive issues. A multidisciplinary approach improves quality of life for patients and families, though disease-modifying therapies are not yet available.

Area of Science:

  • Neurology
  • Genetics
  • Neurodegenerative Diseases

Background:

  • Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder.
  • It manifests with involuntary movements, psychiatric symptoms, and cognitive decline, typically starting in midlife.
  • HD progression leads to increasing disability over 15-20 years.

Purpose of the Study:

  • To outline the diagnostic implications of Huntington's disease for at-risk family members.
  • To emphasize the importance of genetic counseling before DNA testing.
  • To review current management strategies for Huntington's disease.

Main Methods:

  • Review of pharmacologic and non-pharmacologic interventions for symptom management.
  • Discussion of adjunctive therapies including physical, occupational, and speech therapy.

Related Experiment Videos

  • Highlighting the role of social work and support organizations.

    • Main Results:

    • While disease-modifying therapies are unavailable, a multidisciplinary approach significantly improves motor and psychiatric symptoms.
    • Medications can manage specific symptoms, but side effects require ongoing assessment and therapy adjustment.
    • Environmental and pharmacologic strategies can modify both motor and psychiatric symptoms.

    Conclusions:

    • Active treatment of psychiatric symptoms is crucial due to their significant morbidity and responsiveness to therapy.
    • A comprehensive, multidisciplinary management plan enhances function and quality of life for HD patients and their families.
    • Ongoing assessment and adaptation of therapies are essential as the disease progresses.