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Detection of Functional Matrix Metalloproteinases by Zymography
Published on: November 8, 2010
Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor
A B Smith1, T Nittoli, P A Sprengeler
1Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
Organic Letters
|December 2, 2000
Abstract:
[reaction: see text] A pyrrolinone-based hydroxamate matrix metalloprotease inhibitor, (-)-1, has been designed and synthesized. Enzymatic assay revealed that (-)-1 inhibited three of the ten matrix metalloprotease enzymes examined and as such represents a new, potentially important lead structure.
